Christina Applegate and Jamie-Lynn Sigler

Jamie-Lynn Sigler feels giddy about being Conan O’Brien’s friend. Christina Applegate feels awesome about being Conan O’Brien’s friend. Jamie-Lynn and Christina sit down with Conan to discuss their respective MS diagnoses, exploring growth and self-reflection on their podcast MeSsy, and why it’s so important to get specific about your vulnerability. Later, Matt Gourley reveals his family’s eerily accurate Oscars fashion predictions.