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Radiolab

The Medical Matchmaking Machine

August 22, 2025·1h 2m

As he finished his medical school exam, David Fajgenbaum felt off. He walked down to the ER and checked himself in. Soon he was in the ICU with multiple organ failure. The only drug for his condition didn’t work. He had months to live, if that. If he was going to survive, he was going to have to find his own cure. Miraculously, he pulled it off in the nick of time. From that ordeal, he realized that our system of discovering and approving drugs is far from perfect, and that he might be able to use AI to find dozens, hundreds, even thousands of cures, hidden in plain sight, for as-yet untreatable diseases. EPISODE CREDITS: Reported by - Latif Nasser Produced by - Maria Paz Gutiérrez with mixing help from - Jeremy S. Bloom Fact-checking by - Natalie A.