643. Mastering GLP-1s in Peri and Menopause: What 95% of Women Are Doing Wrong

If you're eating well, exercising, prioritizing protein, and still struggling with weight gain in perimenopause or menopause, you're not alone. In this episode, I sit down with hormone expert Karen Martel to talk about why midlife weight gain is often more complex than calories in and calories out. We discuss how shifts in progesterone, estrogen, testosterone, thyroid function, and stress hormones can impact metabolism, cravings, muscle mass, and insulin sensitivity. We also explore hormone replacement therapy, insulin resistance, and the growing use of GLP-1 medications for weight loss. Karen shares what she sees most often in practice, why some women continue to struggle despite doing everything right, and how to think about weight loss resistance through a broader hormonal and metabolic lens. If you've been wondering why your body feels different in midlife, this episode is for you. What you’ll learn: Why weight loss becomes more challenging during perimenopause and menopause How changing hormone levels affect metabolism and body composition The connection between sleep, stress, cravings, and weight gain Why insulin resistance can develop even in women with healthy habits How thyroid health influences weight and metabolic function What hormone replacement therapy can and cannot do for weight loss When GLP-1 medications may be appropriate for midlife women Signs that deeper metabolic or hormonal factors may be contributing to weight loss resistance After listening, you'll have a better understanding of the hormonal changes that shape weight and metabolism in midlife, along with practical considerations for supporting your health. Subscribe, share the episode, and send it to a friend who may be navigating the same challenges.